Blood vancomycin concentration measurements by fluorescence polarization immunization. Effect in renal hypofunction.
نویسندگان
چکیده
منابع مشابه
Effect of protein concentration on the determination of digoxin in serum by fluorescence polarization immunoassay.
Determination of digoxin by fluorescence polarization immunoassay (FPIA) with the Abbott "TDx" is significantly influenced by the concentration of total serum protein. Each 10 g/L increase in serum protein results in an 8% decrease in measured digoxin. Studies with [3H]digoxin confirmed that digoxin binds to the protein pellet during the trichloroacetic acid precipitation step before the immuno...
متن کاملEvaluation of an automated fluorescence polarization immunoassay for vancomycin.
An automated fluorescence polarization immunoassay for the determination of vancomycin levels in serum was evaluated. The vancomycin assay is a homogeneous competitive inhibition immunoassay based on changes in fluorescence polarization that occur with antibody binding. This assay was compared with a liquid chromatographic assay and an agar well diffusion bioassay method by using clinical serum...
متن کاملEffect of concentration polarization on permselectivity.
In this paper, the variation of permselectivity in the course of concentration polarization is systematically analyzed for a three-layer membrane system consisting of a nonperfectly permselective ion exchange membrane, homogeneous or heterogeneous, flanked by two diffusion layers of a binary univalent electrolyte. For a heterogeneous membrane, an ionic transport model is proposed, which is amen...
متن کاملWhole-blood calcineurin activity is not predicted by cyclosporine blood concentration in renal transplant recipients.
BACKGROUND In transplant patients, current cyclosporine (CsA) dose monitoring with classic pharmacokinetics has demonstrated limitations. Evaluation of the activity of calcineurin (CN), the serine-threonine phosphatase enzyme target of CsA, has been proposed as a reliable way to optimize CsA dosing. METHODS CN activity was measured in whole blood in an attempt to overcome the high variability...
متن کاملBlood lead concentration, blood pressure, and renal function.
Blood lead concentrations were related to blood pressure and indicators of renal function in a clinical survey of 7735 middle aged men from 24 British towns. There was no overall evidence that blood lead concentrations were associated with systolic or diastolic blood pressure (r = +0.03 and +0.01, respectively). In the 74 men with a blood lead concentration of 1.8 mumol/l (37.3 micrograms/100 m...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1997
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.28.307